A method is provided for using at least one response bubble on a response form to indicate one or more responses. The response form has a key definition area that includes one or more response bubbles corresponding to one or more intended responses, and a response area that includes one or more response bubbles for indicating intended responses. A response form is completed by defining an unambiguous symbology of one or more marks by completing the key definition area, and filling in the response area using the defined unambiguous symbology. The response form is then electronically imaged. The unambiguous symbology is then automatically interpreted from the key definition area of the response form. The indicated intended responses of the one or more response bubbles of the completed response form are automatically interpreted using the interpreted unambiguous symbology, and the electronically imaged completed response form.